Endocrine Abstracts

Background: Autoimmune destruction is the most common aetiology of primary adrenal insufficiency (PAI) in Europe and north America. In contrast, tuberculosis is a common cause of PAI in developing countries. More recently, adrenal histoplasmosis (AH) is being increasingly reported from IndiaAims: To study the aetiology, clinical presentation and mortality in adults with PAI who were diagnosed between 2006-2019 and to determine the changes in aetiology si...

Background: Data examining HLA associations in Addison’s disease (AD) from South Africa (SA) are limited. We wished to determine the HLA in South African AD patients either positive or negative for 21 hydroxylase autoantibodies (21 OH-AA) and matched healthy controls, hypothesising that certain HLA alleles could predominate, but there may be differences from Western countries.Methods: SA patients (n=73) were enrolled as part of a nationwide...

Introduction: Autoimmune polyendocrine syndrome 1 (APS1) is an uncommon, serious autosomal recessive disorder, due to AIRE gene mutations which result in impaired central tolerance. India has a complex genetic structure and also communities with high prevalence of consanguinity, which may result in varied clinical manifestations and genetic mutations.Aims: To study clinical features, interferon-α antibodies (IFNA), AIRE mutations, ...